v30.6 · 2026-05-23
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You found this for a reason.
Choose where to start.
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Start at the source — the mouth
Parasites enter through the mouth. Periodontitis drives cancer, Alzheimer's, heart disease & autoimmunity — everything downstream.
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Calculate your protocol — free
Weight-based dosing for ivermectin, fenbendazole & mebendazole.
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The research, in your hands
73 peer-reviewed studies across cancer, oral, neuro, cardio, autoimmune, metabolic & reproductive health. The parasitic root of chronic disease.
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Where to source compounds
Trusted suppliers for IVM, FBZ & MBZ — no counterfeits.
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For my pet
Veterinary protocols — dogs, cats, horses & more.
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Community
Forums, shared experiences, and peer support.
Not medical advice. These compounds are not FDA-approved for cancer treatment. All data stays in your browser. Consult a healthcare provider.
What stage is your diagnosis?
1
Early, localized
2
Locally advanced
3
Regionally advanced
4
Metastatic
What type of cancer?
Optional but helpful: We'll highlight the most relevant research for your cancer type on the Research tab, and surface any known compound synergies on your dose page.
Your approximate body weight?
Why we ask: These protocols are dosed by body weight, just like many prescription medications. Ivermectin, for example, is calculated at a specific milligram amount per kilogram of body weight. Getting this right helps ensure you're seeing accurate numbers for your situation — not a generic estimate.
165lbs
74.8 kg
80 lbs1000 lbs
What form of ivermectin do you have?
Why this matters: Ivermectin comes in very different concentrations depending on the product. A 1.87% OTC paste syringe, a liquid cattle drench, and a compounded pharmacy tablet all contain the same active ingredient — but at wildly different strengths. Getting the math wrong here means your actual dose could be 10× too high or too low. Select what you have (or plan to get) and we'll show you exactly how much to use.
Select your ivermectin format above to see your dose.
🐾 Pet Protocol
What kind of pet?
🐕 Dog Breed
What breed?
This matters. Several breeds carry the MDR1/ABCB1 gene mutation that makes ivermectin potentially fatal at doses that are safe for other dogs.
⚠ = MDR1 mutation risk. These breeds will receive a fenbendazole-only protocol.
🛑 Ivermectin is not safe for this breed
Collies, Australian Shepherds, Shelties, Border Collies, and related herding breeds frequently carry the MDR1 (ABCB1) gene mutation. This mutation prevents the blood-brain barrier from pumping ivermectin out of the brain, causing ivermectin to accumulate to toxic and potentially fatal levels — even at doses that are completely safe in other dogs.
We have automatically excluded ivermectin from your pet's protocol. Your pet can still benefit from fenbendazole (FBZ), which does not carry this risk.
We have automatically excluded ivermectin from your pet's protocol. Your pet can still benefit from fenbendazole (FBZ), which does not carry this risk.
🐾 Pet Protocol
What's their name?
🐾 Pet Protocol
How much does your pet weigh?
50lbs
22.7 kg
2 lbs1,500 lbs
🐾 Pet Protocol
What is the goal?
🧬 Active cancer diagnosis
Protocol support for a current cancer diagnosis in your pet.
🦹 Parasite treatment
Treatment of known or suspected parasitic infection.
🛡️ Prevention / maintenance
Prophylactic low-dose protocol for long-term wellness.
How this works: Based on your goal and body weight, we calculate starting doses drawn from peer-reviewed studies and community-observed protocols. These numbers are a research reference — bring them to a knowledgeable physician or telemedicine provider who can review your full health picture before you begin.
165
lbs
(74.8 kg)
Protocol Tracker
Protocol Tracker
Track your progress — enter the date you started (or plan to start) your protocol.
✅ Fatigue, brain fog, mild headache
Likely die-off (Herx reaction). Increase your binder dose — take it 2–3 hours after each compound dose, never before. Drink more water. Rest. These symptoms usually peak around days 2–5 and fade as your body clears the debris. Do not stop your protocol.
✅ Nausea, loose stools, mild joint aches
Likely die-off or absorption issue. Take ivermectin and fenbendazole with a larger fatty meal. Try splitting your fenbendazole dose across two meals. Add a binder dose at bedtime. Continue protocol.
⚠️ Persistent nausea, loss of appetite, upper right abdominal pain
Possible liver strain. Pause your protocol immediately. Continue taking binders during the pause to help clear circulating toxins. Get liver function tests (AST/ALT) immediately. Resume only when levels normalize — and when you do, take binders 2–3 hours after each dose, never before. Consider dropping one dose tier.
🛑 Yellowing skin or eyes (jaundice), severe abdominal pain, shortness of breath, vision changes, severe rash
Stop the protocol immediately and seek emergency care. These are not Herxheimer symptoms. Call 911 or go to an emergency room.
Stay Updated
Research alerts, protocol updates, and community highlights.
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Oral-Systemic Health
The mouth as the upstream gateway to chronic disease.
Mainstream medicine treats chronic disease at the downstream end — statins for cholesterol, biologics for inflammation, chemo for tumors. But chronic infections — protozoa, helminths, and inflammation-driving bacteria — sit upstream of nearly every system. The oral cavity is the most accessible window into this, and the best-documented gateway. The pattern below repeats across organs: parasites and chronic infections drive inflammation → inflammation drives tissue damage → tissue damage manifests as the diseases we call cardiovascular, neurodegenerative, autoimmune, metabolic, and oncologic.
Tap any section to expand
🦷The Oral Gateway▼
🧬 The mouth hosts protozoa that destroy tissue. Entamoeba gingivalis exhibits trogocytosis — literally nibbling host cells — the same mechanism as its colonic cousin E. histolytica. Bao et al, JDR 2020
📊 Detected in 77% of periodontitis patients vs 15% of healthy controls. One of the strongest epidemiological signals for parasitic involvement in any common disease. Bonner et al, Parasite 2014
💊 Metronidazole + amoxicillin adjunct therapy works partly because it kills these protozoa, not just anaerobic bacteria. Sgolastra et al, J Periodontol 2012
💡 Upstream intervention: anti-protozoal oral hygiene (mechanical + antimicrobial) shifts the entire downstream cascade described below.
🧠Brain & Cognition▼
🔬 P. gingivalis gingipains in postmortem Alzheimer's brain tissue. Oral infection in mice produced brain colonization and amyloid-β response. Dominy et al, Science Advances 2019
💊 Spawned the COR388/atuzaginstat clinical program. The trial failed Phase 2/3 endpoints (a gingipain inhibitor wasn't enough on its own), but the underlying mechanism evidence stands.
🧠 Other neuro-parasite links: T. gondii (latent toxoplasmosis affects ~30% of humans), neurocysticercosis (top cause of adult-onset epilepsy globally), chronic Lyme.
💡 Upstream intervention: oral hygiene + cyst-permeable antimicrobials are increasingly being explored for cognitive decline. AntiparasitIQ's compound stack already crosses the blood-brain barrier.
❤️Cardiovascular▼
🩸 P. gingivalis DNA detected directly in atherosclerotic plaques from coronary artery bypass patients. Direct evidence of oral bacteria translocated into vascular lesions. Mahendra et al, 2013
📈 Periodontitis ~2× coronary heart disease risk across 20+ years of replicated meta-analyses.
🔥 Mechanism: chronic bacteremia + LPS-driven endothelial inflammation. The same inflammation cascade statins try to dampen downstream.
💡 Upstream intervention: treating periodontitis is functionally a cardiovascular prevention strategy — and is dramatically cheaper than lifetime statin therapy.
🛡Autoimmune▼
🧬 Aggregatibacter actinomycetemcomitans hypercitrullinates host proteins → anti-CCP antibody response → rheumatoid arthritis. Strongest known molecular link between an oral infection and an autoimmune disease. Konig et al, Sci Transl Med 2016
🔀 Molecular mimicry as a general mechanism. The autoimmune category contains a growing fraction of conditions where the immune system is responding to chronic, undetected infection rather than self-tissue.
💡 Upstream intervention: targeted dental therapy may be RA prevention. Broader principle: rule out chronic infection before accepting an autoimmune diagnosis.
🍯Metabolic▼
🔁 Periodontitis ↔ diabetes is bidirectional. Treating periodontitis lowers HbA1c ~0.4% — comparable to adding a second oral hypoglycemic. EFP/IDF consensus. Sanz et al, J Clin Periodontol 2018
🔥 Mechanism: systemic inflammation drives insulin resistance. Chronic periodontal inflammation = chronic systemic inflammation = metabolic dysfunction.
💡 Upstream intervention: dental care as glycemic intervention. The biggest single non-pharmaceutical HbA1c lever most diabetics never hear about.
🤱Reproductive▼
👶 Periodontal infection → preterm low birth weight. Offenbacher's foundational 1996 study launched 25+ years of follow-on research. Offenbacher et al, J Periodontol 1996
📜 AAP/EFP workshop consensus: periodontitis associated with preterm birth, preeclampsia, low birth weight. Mechanism: systemic inflammation + direct bacterial translocation to placenta. Bobetsis et al, J Periodontol 2020
💡 Upstream intervention: preconception and prenatal oral health screening is high-leverage, low-cost. Standard prenatal care still under-prioritizes it.
🧬Cancer (closing the loop)▼
🧫 F. nucleatum (oral-origin bacterium) drives colorectal cancer metastasis and chemoresistance. Found in CRC tumors AND in matched liver metastases. Antibiotic depletion reduced tumor burden in mouse xenografts. Bullman et al, Science 2017
📊 Periodontal disease → 64% ↑ pancreatic cancer risk over 16 years follow-up in the Harvard HPFS cohort (n=51,529). Michaud et al, JNCI 2007
🐛 Liver flukes → cholangiocarcinoma. Direct parasite-cancer causation. Luvira et al, 2018
💡 Upstream intervention: antiparasitic strategy as cancer prevention, not just treatment. The IVM/FBZ/MBZ protocols target the tumor — but the upstream parasitic drivers can be addressed before tumorigenesis even begins.
Why this is rare leverage. The IVM/FBZ/MBZ protocols target cancer cells directly. But the same compounds — and adjacent antiparasitics like metronidazole and nitazoxanide — also clear the upstream infections that drive nearly every chronic disease. Antiparasitic intervention is one of the most leverage-rich strategies in medicine: it sits at the root of the cascade, not the symptom. The Research database catalogs both fronts — the cancer evidence and the systemic-axis evidence — so you can filter by domain and read the primary sources yourself.
Stay Updated
Research alerts and protocol updates for the oral-systemic axis.
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AntiparasitIQ Community
A private space for people navigating antiparasitic protocols — sharing experiences, tracking progress, and supporting each other through the process.
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Protocol discussions
What's working, what isn't, dosing questions, and real experiences from people on the same path.
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Research updates
New studies, clinical trial results, and protocol refinements shared as they emerge.
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Pet protocols
A dedicated space for veterinary experiences — dogs, cats, horses, and more.
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Peer support
People who understand. No judgment, no gatekeeping — just honest conversation about a difficult journey.
Opens in a new tab · community.antiparasitiq.com
Stay Updated
Get notified about new research, protocol updates, and community highlights.
Ivermectin, fenbendazole, and mebendazole all process through the liver. Get a baseline before you start anything above the Low tier so you know what's normal for you, and re-test on the cadence below. The published Baghli/Marik/Makis 2024 protocol calls for weekly liver function tests at the High and Advanced tiers. Case reports describe drug-induced liver injury when fenbendazole is combined with checkpoint inhibitor immunotherapy (Keytruda/pembrolizumab, Opdivo/nivolumab) — if you're on either, talk to your oncologist before starting.
What to test
AST, ALT, GGT, and total bilirubin (TBILI) are the four core liver markers. The kit below also includes HbA1c (blood glucose), HsCRP (inflammation), and a full metabolic snapshot — useful baseline data even outside this protocol.
When to test
Once before starting (any tier above Low) · every 1–2 weeks during High or Advanced tiers · once at protocol end.
Recommended test kit
7-Marker At-Home Liver + Metabolic Test Kit
CLIA-certified · finger-prick · results in days
AST, ALT, GGT, TBILI, HbA1c, HsCRP, plus one more. Mail-in collection kit. Affiliate link — supports the project at no cost to you.
Affiliate link — we may earn a commission at no cost to you. Not medical advice.
⚠ What is a Herxheimer reaction?
When antiparasitics kill parasites and cancer cells, the dying cells release a flood of toxins — heavy metals, bacterial waste, mold byproducts, and cell debris — faster than your liver and kidneys can clean them out. This toxic overload washes back into your bloodstream. The result — known as a “Herx reaction” or die-off — is sudden fatigue, brain fog, headaches, nausea, joint pain, and flu-like symptoms. Many people think this is a bad reaction to the medication and stop the protocol. It's not. The medication is working — but the waste has nowhere to go. Binders give it an exit route.
Dose & Timing
📏 Start at 1 g activated charcoal per dose, 1–2× daily. Work your way up to 2–3 g per dose only if die-off symptoms (fatigue, headache, nausea) are strong. Stop increasing if you get constipated — that's your body's limit.
⏱ Take binders 2–3 hours after each ivermectin, fenbendazole, or mebendazole dose — never before.
📅 Start binders 3–5 days before beginning the protocol to prepare your body's detox system.
Activated charcoal binds anything it touches in your gut — it can't tell the difference between die-off toxins and your medication. If taken before a compound dose, it traps the medication and stops it from being absorbed. The same rule applies to any other pill you take by mouth (thyroid, birth control, antidepressants, etc.) — space them by at least 2 hours. Taking charcoal every day for a long time can also soak up vitamins (A, D, E, K) and minerals, so talk to a doctor if you plan to use it for more than a few weeks.
Pick Your Binder
Three options, same primary active ingredient. Pick based on protocol length and convenience vs. cost.
Durvet Activated Charcoal Gel — 80 mL · Tractor Supply
⭐ Starter
Pre-measured syringe with mL graduations. Activated charcoal (100 mg/mL) + attapulgite clay (200 mg/mL) + electrolytes. Best for: a trial run, pets, zero-prep dosing. Lasts ~1–2 days of dosing for a typical adult — step up to ToxiBan below for multi-week protocols. Start 3–5 days before your first dose; take 2–3 hours after each compound dose.
ToxiBan Charcoal-Kaolin Suspension — 240 mL · Tractor Supply
💰 Best value
Pourable liquid suspension. Activated charcoal (104 mg/mL) + kaolin clay (62.5 mg/mL). 3× the volume of the 80 mL Durvet tube, same charcoal dose per mL. Best for: multi-week protocols, one-stop Tractor Supply shopping. Measure with an oral syringe.
Herbal Complement
Detoxify Advanced Body Cleanse
Herbal Formula
Black walnut, papaya seed, chlorella, psyllium, aloe fiber. Vegan, non-GMO, gluten-free. Complements the binder — not a binder itself.
Affiliate links — we may earn a commission at no cost to you. Not medical advice.
Tractor Supply Co.
Ivermectin (IVM) · Over-the-counter paste
Order online or pick up in-store. Tractor Supply Co. carries 1.87% ivermectin paste OTC — one of the most reliable and widely available sources.
More suppliers coming soon
Ivermectin (IVM)
Additional verified sourcing options are being vetted. Check back soon.
Tractor Supply Co.
Fenbendazole (FBZ) · SafeGuard
SafeGuard goat or dog dewormer. 222 mg or 444 mg packets. Order online or pick up in-store from Tractor Supply Co.
More suppliers coming soon
Fenbendazole (FBZ)
Additional verified sourcing options are being vetted. Check back soon.
Coming Soon
Mebendazole requires a prescription in the United States. We are working to add a verified telehealth supplier. Subscribe below to be notified when sourcing is available.
Companion Supplements
Take 6–8 hours after ivermectin and fenbendazole doses. Affiliate links support AntiparasitIQ at no extra cost to you.
Magnesium Complex
5 forms: citrate, glycinate, malate, oxide, Aquamin
Broad-spectrum mineral support
Amazon →Colon Cleanse Detox
Psyllium + Probiotics + Bentonite Clay
Gut transit, bloating, die-off support
Amazon →Turmeric Curcumin
655 mg · 95% curcuminoids + BioPerine + Ginger
Core protocol, anti-inflammatory
Amazon →Stay Updated
Get notified when new suppliers are vetted and added.
About our sourcing
The suppliers above (Tractor Supply, Amazon, US-licensed pharmacies for prescription items) are curated because counterfeits are prevalent in this space. If you go elsewhere: avoid unverified marketplace sellers, social-media ads, and overseas sites without a verifiable address. For veterinary products, stick to name-brand from established retailers; for human prescription items, only US-licensed pharmacies.
🐾 Pet sourcing — For veterinary protocols, use name-brand products from established retailers. Tractor Supply Co. carries verified product — order online or pick up in-store. Consult your veterinarian before giving your pet any compound.
Affiliate disclosure: Product links on this page may be affiliate links. AntiparasitIQ may earn a commission at no additional cost to you. Not veterinary medical advice — use at your own risk.
Your compounds
Tractor Supply Co.
Fenbendazole (FBZ) · SafeGuard
SafeGuard goat or dog dewormer. 222 mg or 444 mg packets. Order online or pick up at Tractor Supply Co.
More suppliers coming soon
Fenbendazole (FBZ)
Additional verified sourcing options are being vetted.
⚠ Sourcing warning: For veterinary products, use name-brand only from established retailers like Tractor Supply Co. Avoid unverified marketplace sellers and social media ads.
Stay Updated
Get notified when new pet suppliers are vetted and added.
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