AntiparasitIQ
Your Personalized Research Reference
Protocol information tailored to your selected goal. All data is stored locally in your browser and never transmitted.
50Studies
20+Cancer Types
15IVM Mechanisms
12FBZ Mechanisms
Your Results
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Sourcing
Trusted Suppliers
Sourcing matters. Counterfeit and mislabeled product is rampant in this space, particularly for fenbendazole sold through unverified online sellers. These are established, reputable suppliers with verified product sourcing.
Jeffers Pet
Fenbendazole (Veterinary)
Established veterinary supply company carrying name-brand fenbendazole products (Panacur, SafeGuard) with verified concentrations. Trusted by veterinarians and livestock operations nationwide.
Visit Jeffers Pet
Tractor Supply Co.
Fenbendazole (Veterinary)
National retailer with brick-and-mortar locations. Carries SafeGuard and other name-brand fenbendazole products. In-store purchasing eliminates shipping chain-of-custody concerns.
Visit Tractor Supply
The Wellness Company
Ivermectin + Mebendazole (Human Rx)
Telehealth platform offering prescription ivermectin and mebendazole for human use. Prescribed by licensed medical professionals, compounded and dispensed by a licensed US-based pharmacy.
Visit TWC Health
Sourcing warning: Be cautious of fenbendazole sold through unverified online marketplaces, social media ads, or websites with no verifiable business address. Counterfeit products may contain incorrect concentrations, contaminants, or no active ingredient at all. When possible, purchase name-brand products (Panacur, SafeGuard) from established retailers with traceable supply chains.
Full Reference
All Dosing Protocols
Ivermectin Tiered Dosing
Source: Dr. William Makis protocols (community-observed, not from RCTs)
Tier
Dosage
Indication
Low
≤ 0.5 mg/kg
3 on, 4 off
3 on, 4 off
Remission, family history, prophylaxis. Min 7 weeks.
Medium
1.0 mg/kg/day
6 on, 1 off
6 on, 1 off
Starting dose for most active cancers. Min 3 months.
High
2.0 mg/kg/day
6 on, 1 off
6 on, 1 off
Aggressive cancers: leukemia, pancreas, brain.
Very High
≥ 2.5 mg/kg/day
6 on, 1 off
6 on, 1 off
Terminal, extensive metastatic. Short-term.
Ivermectin Calculator
165lbs/74.8kg
Fenbendazole Tiered Dosing
Source: Community protocols, Dr. Makis observations, Joe Tippens derivatives
Tier
Dosage
Indication
Low
222 mg/day
3 on, 4 off
3 on, 4 off
Remission, prophylaxis. Original Tippens dose.
Medium
222-444 mg/day
6 on, 1 off
6 on, 1 off
<200 lbs: 222mg. >200 lbs: 444mg. Min 3 months.
High
444-888 mg/day
6 on, 1 off
6 on, 1 off
Aggressive/Stage 4. 888mg split 2x444mg.
Very High
888-2000 mg/day
6 on, 1 off
6 on, 1 off
Extensive metastatic. Up to 2000mg reported.
Fenbendazole Calculator
165lbs/74.8kg
Mebendazole Dosing
Source: Clinical trials + community protocols. Mebendazole IS FDA-approved (antiparasitic).
Tier
Dosage
Indication
Low
100-200 mg/day
UK trial (100mg), adrenocortical (200mg), colon cancer (200mg).
Medium
200-500 mg/day
Community protocols. Often 200-400mg alongside IVM.
High
500-1500 mg/day
Phase 1 pediatric brain tumors range.
Very High
Up to 2400 mg/day
Phase 2 GBM: 800mg x3/day. Up to 4g/day safe (Mansoori 2021).
CONTRAINDICATION: Never combine mebendazole (>500mg) with metronidazole (>500mg) — risk of Stevens-Johnson syndrome (Chen 2003). Mebendazole dosing is fixed (not weight-based).
Modified Joe Tippens Protocol (2026)
Baghli et al 2024 (J. of Orthomolecular Medicine). Co-authors: Marik, Makis.
Daily Protocol
Ivermectin24mg, 6 days/wk
Fenbendazole300mg, 6 days/wk
OR Mebendazole200-400mg/day
Vitamin D32,500 IU daily
Bio-available Curcumin600mg daily
Enhanced Berberine500mg daily
Take with fatty foods. Ketogenic diet shown to enhance mebendazole efficacy (Mukherjee 2023). Target sugar below 25g/day. Vitamin E removed in 2020 due to blood thinner interactions.
Database
Research Database
Science
Mechanisms of Action
Ivermectin (15 identified)
01 Microtubule destabilization
02 Akt/mTOR pathway inhibition
03 Wnt/β-catenin pathway inhibition
04 Apoptosis via mitochondrial dysfunction
05 ROS generation
06 Cancer stem cell inhibition
07 Glycolysis inhibition
08 DNA damage (NHEJ impairment)
09 Angiogenesis inhibition
10 Multidrug resistance reversal
11 PAK1 signaling inhibition
12 PAK1 protein degradation
13 STAT3 pathway modulation
14 T-cell infiltration (cold→hot tumors)
15 NET abrogation
Fenbendazole (12 identified)
01 Microtubule destabilization (β-tubulin)
02 p53 mitochondrial translocation
03 Glucose uptake / GLUT inhibition
04 Hexokinase II (HK II) inhibition
05 Proteasomal impairment
06 G2/M cell cycle arrest
07 Apoptosis induction
08 Pyroptosis (HK2/caspase-3/GSDME)
09 Cancer stem cell targeting
10 Wnt pathway inhibition
11 Oxidative stress induction
12 Dual: bulk tumor + stem cells
History
Key Timeline
1970s
Omura isolates Streptomyces avermitilis from soil near a Japanese golf course. Campbell at Merck purifies avermectin → ivermectin.
1981
Ivermectin approved for veterinary use.
1987
Human use begins. Merck donates Mectizan for river blindness. 25M people treated/year across 33 countries.
2015
Nobel Prize awarded to Campbell and Omura.
2016
Joe Tippens: lung cancer diagnosis, begins FBZ 222mg + supplements. PET scan clear after 3 months.
2018
Foundational paper in Nature/Sci Reports: FBZ as microtubule agent, multiple anti-cancer pathways. 605k accesses.
2024
First peer-reviewed IVM+MBZ+FBZ protocol published. Oxfendazole Phase I safety data: tolerability at 60mg/kg.
2025
Cedars-Sinai Phase I/II: IVM + balstilimab for mTNBC shows 37.5% CBR at ASCO. 550+ case reports compiled.
2026
Research ongoing. Trial continuing. Community growing to 100k+ members.
Critical
Safety and Contraindications
Critical Contraindication
Never combine mebendazole (>500mg) with metronidazole (>500mg). Rare but potentially fatal Stevens-Johnson syndrome. (Chen 2003)
Monitoring Requirements
FBZ: Liver function (AST/ALT) regularly. Not FDA-approved for humans.
MBZ: Liver + kidney function. FDA-approved antiparasitic. Safe up to 4g/day (Mansoori 2021).
IVM: Nobel Prize drug. Billions of human doses at parasite dosing. Cancer protocols use 5-12x standard dose.
All: Take with fatty food. Weekly LFTs at high doses. Consult a healthcare provider.